Digital vascular responses and serum endothelin-1 concentrations in primary and secondary Raynaud's phenomenon

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Digital vascular responses and serum endothelin-1 concentrations in primary and secondary Raynaud's phenomenon.

OBJECTIVE To determine circulating endothelin-1 levels (ET-1) in patients with primary or secondary associated Raynaud's phenomenon (RP) under resting conditions and in response to cold provocation. METHODS Patients were categorised as primary RP (18) or scleroderma associated RP (14). Finger blood flow was measured by venous occlusion plethysmography at finger temperatures of 32 degrees C an...

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Increased asymmetric dimethylarginine and endothelin 1 levels in secondary Raynaud's phenomenon: implications for vascular dysfunction and progression of disease.

OBJECTIVE To compare microvascular and macrovascular functions in a cohort of patients with primary and secondary Raynaud's phenomenon (RP) who were matched for demographic, risk factor, and severity profiles. METHODS Forty patients with primary or secondary RP matched for vascular risk factors and severity scores underwent testing of endothelial function and cold pressor responsiveness of th...

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ژورنال

عنوان ژورنال: Annals of the Rheumatic Diseases

سال: 2000

ISSN: 0003-4967

DOI: 10.1136/ard.59.11.870